Faculty of Natural
Sciences
Comenius University Bratislava

PUBLICATIONS

2022

Ezquerra-Aznárez, J. M.; Degiacomi, G.; Gašparovič, H.; Stelitano, G.; Sammartino, J. C.; Korduláková, J.; Governa, P.; Manetti, F.; Pasca, M. R.; Chiarelli, L. R.; Ramón-García, S., The veterinary anti-parasitic selamectin is a novel inhibitor of the Mycobacterium tuberculosis DprE1 enzyme. International Journal of Molecular Sciences 2022, 23(2):771. Doi: 10.3390/ijms23020771.

2021

Pflégr, V., Maixnerová, J.; Stolaříková, J.; Pál, A.; Korduláková, J.; Trejtnar, F.; Vinšová, J.; Krátký, M., Design and synthesis of highly active antimycobacterial mutual esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic acid. Pharmaceuticals 2021, 14(12), 1302. Doi: 10.3390/ph14121302

Pflégr, V.; Horváth, L.; Stolaříková, J.; Pál, A.; Korduláková, J.; Bosze, S.; Vinšová, J.; Krátký, M., Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity. European Journal of Medicinal Chemistry 2021, 223: 113668. Doi: 10.1016/j.ejmech.2021.113668

Farjallah, A.; Chiarelli, L. R.; Forbak, M.; Degiacomi, G.; Danel, M.; Goncalves, F.; Carayon, C.; Seguin, C.; Fumagalli, M.; Záhorszká, M.; Vega, E.; Abid, S.; Grzegorzewicz, A.; Jackson, M.; Peixoto, A.; Korduláková, J.; Pasca, M. R.; Lherbet, C.; Chassaing, S., A coumarin-based analogue of thiacetazone as dual covalent inhibitor and potential fluorescent label of HadA in Mycobacterium tuberculosis. ACS Infectious Diseases 2021, 7(3): 552-565. Doi: 10.1021/acsinfecdis.0c00325

Madacki, J.; Kopál, M.; Jackson, M.; Korduláková, J., Mycobacterial epoxide hydrolase EphD is inhibited by urea and thiourea derivatives. International Journal of Molecular Sciences 2021, 22(6). Doi: 10.3390/ijms22062884

Fan, D.; Wang, B.; Stelitano, G.; Savková, K.; Shi, R.; Huszár, S.; Han, Q.; Mikušová, K.; Chiarelli, L. R., Lu, Y.; Qiao, C., Structural and activity relationships of 6-sulfonyl-8-nitrobenzothiazinones as antitubercular agents. Journal of Medicinal Chemistry 2021, 64(19): 14526-14539. Doi: 10.1021/acs.jmedchem.1c01049

Savková, K., Huszár, S.; Baráth, P.; Pakanová, Z.; Kozmon, S.; Vancová, M.; Tesařová, M.; Blaško, J.; Kaliňák, M.; Singh, V.; Korduláková, J.; Mikušová, K., An ABC transporter Wzm-Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria. Proceedings of the National Academy of Sciences of the United States of America 2021, 118(17). Doi: 10.1073/pnas.2023663118

Monakhova, N., Korduláková, J.; Vocat, A.; Egorova, A.; Lepioshkin, A.; Salina, E. G.; Nosek, J.; Repková, E.; Zemanová, J.; Jurdáková, H.; Górová, R.; Roh, J.; Degiacomi; Sammartino, J. C.; Pasca, M. R.; Cole, S. T.; Mikušová, K.; Makarov, V., Design and synthesis of pyrano[3,2-b]indolones showing antimycobacterial activity. ACS Infectious Diseases 2021 7(1): 88-100. Doi: 10.1021/acsinfecdis.0c00622

 Liu, R.; Markley, L.; Miller, P. A.; Franzblau, S.; Shetye, G.; Ma, R.; Savková, K.; Mikušová, K.; Lee, B. S.; Pethe, K.; Moraski, G. C.; Miller, M. J., Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds. RSC Medicinal Chemistry 2021, 12(1): 62-72. Doi: 10.1039/d0md00390e

2020

Li, M., Gašparovič, H.; Weng, X., Chen, S.; Korduláková, J.; Jessen-Trefzer, C., The Two-component locus MSMEG_0244/0246 together with MSMEG_0243 affects biofilm assembly in M. smegmatis correlating with changes in phosphatidylinositol mannosides acylation. Frontiers in Microbiology 2020, 11:570606. Doi: 10.3389/fmicb.2020.570606

Baráth, M.; Jakubčinová, J.; Konyariková, Z.; Kozmon, S.; Mikusova, K.; M. Bella, Synthesis, docking study and biological evaluation of D-fructofuranosyl and D-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2. Beilstein Journal of Organic Chemistry 202016: 1853-1862. Doi: 10.3762/bjoc.16.152. eCollection 2020

Makarov, V.; Mikušová, K., Development of macozinone for TB treatment: an update. Applied Sciences 2020, 10 (7). Doi: 10.3390/app10072269

Huszár, S.; Chibale, K.; Singh, V, The quest for the holy grail: new antitubercular chemical entities, targets and strategies. Drug Discovery Today 202025(4): 772-780. Doi: 10.1016/j.drudis.2020.02.003

Chiarelli, L. R.; Salina, E. G. ; Mori, G.; Azhikina, T.; Riabova, O.; Lepioshkin, A.; Grigorov, A.; Forbak, M.; Madacki, J.; Orena, B. S.; Manfredi, M.; Gosetti, F.; Buzzi, A.; Degiacomi, G.; Sammartino, J. C.; Marengo, E.; Korduláková, J.; Riccardi, G.; Mikušová, K.; Makarov, V.; Pasca, M. R., New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053. ACS Infectious Diseases 20206 (2): 313-323. Doi: 10.1021/acsinfecdis.9b00388

Sabbah, M.; Mendes, V.; Vistal, R. G.; Dias, D. M. G.; Záhorszka, M.; Mikušová, K.; Korduláková, J.; Coyne, A. G.; Blundell, T. L., Abell, C., Fragment-based design of Mycobacterium tuberculosis InhA Inhibitors. Journal of Medicinal Chemistry 2020, 63(9): 4749-4761. Doi: 10.1021/acs.jmedchem.0c00007

Konyariková, Z.; Savková, K.; Kozmon, S.; Mikušová, K., Biosynthesis of galactan in Mycobacterium tuberculosis as a viable TB drug target? Antibiotics 2020, 9 (1). doi: 10.3390/antibiotics9010020

2019

Dutta, A. K.; Choudhary, E.; Wang, X.; Záhorszka, M.; Forbak, M.; Lohner, P.; Jessen, H. J.; Agarwal, N.; Korduláková, J.; Jessen-Trefzer, C., Trehalose conjugation enhances toxicity of photosensitizers against mycobacteria. ACS Central Science 2019, 5 (4), 644-650. doi: 10.1021/acscentsci.8b00962

Karabanovich, G.; Dušek, J.; Savková, K.; Pavliš, O.; Pávková, I.; Korábečný, J.; Kučera, T.; Kočová Vlčková, H.; Huszár, S.; Konyariková, Z.; Konečná, K.; Janďourek, O.; Stolaříková, J.; Korduláková, J.; Vávrová, K.; Pávek, P.; Klimešová, V.; Hrabálek, A.; Mikušová, K.; Roh, J., Development of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues as highly efficient antitubercular agents inhibiting decaprenylphosphoryl-beta-d-ribofuranose 2'-oxidase. Journal of Medicinal Chemistry 2019, 62 (17), 8115-8139. doi: 10.1021/acs.jmedchem.9b00912

Hajian, B.; Scocchera, E.; Shoen, C.; Krucinska, J.; Viswanathan, K.; G-Dayanandan, N.; Erlandsen, H.; Estrada, A.; Mikušová, K.; Korduláková, J.; Cynamon, M.; Wright, D., Drugging the folate pathway in Mycobacterium tuberculosis: the role of multi-targeting agents. Cell Chemical Biology 2019, 26 (6), 781-791 e6. doi: 10.1016/j.chembiol.2019.02.013

2018

Vosátka, R.; Krátký, M.; Švarcová, M.; Janoušek, J.; Stolaříková, J.; Madacki, J.; Huszár, S.; Mikušová, K.; Korduláková, J.; Trejtnar, F.; Vinšová, J., New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action. European Journal of Medicinal Chemistry 2018, 151, 824-835. doi: 10.1016/j.ejmech.2018.04.017

Salina, E.G.; Huszár, S ; Zemanová, J ; Keruchenko, J.; Riabova, O.; Kazakova, E.; Grigorov, A ; Azhikina, T.; Kaprelvants, A.; Mikušová, K.; and Makarov, V., Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones. Metallomics, 2018,10, 992-1002. doi:10.1039/C8MT00067K

 Mori, M.; Orena, B.S; Franch, C.; Mitchenall, L.A.; Godbole, A.A.; Rodrigues, L.; Aguilar-Pérez, C.; Zemanová, J.; Huszár, S.; Forbak, M.; Lane, T.R.; Sabbah, M.; Deboosere, N.; Frita, R.; Vandeputte, A.; Hoffmann, E.;Russo, R.; Connell, N.; Veilleux, C.; Jha, R.K.; Kumar, P.; Freundlich, J.S.; Brodin, P.; Aínsa, J.A.; Nagaraja, V.; Maxwell, A.; Mikušová, K.; Pasca, M.R.; Ekins, S. The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. Science Direct, Tuberculosis, Volume 112, Pages 98-109, 2018. doi.org/10.1016/j.tube.2018.08.004

Madacki, J.; Laval, F.; Grzegorzewicz, A.; Lemassu, A.; Záhorszká, M.; Arand, M.; McNeil, M.; Daffé, M.; Jackson, M.; Lanéelle, M. A.; Korduláková, J., Impact of the epoxide hydrolase EphD on the metabolism of mycolic acids in mycobacteria. Journal of Biological Chemistry 2018, 293 (14), 5172-5184. doi: 10.1074/jbc.RA117.000246

Chiarelli, L. R.; Mori, G.; Orena, B. S.; Esposito, M.; Lane, T.; de Jesus Lopes Ribeiro, A. L.; Degiacomi, G.; Zemanova, J.; Szadocka, S.; Huszár, S.; Palčeková, Z.; Manfredi, M.; Gosetti, F.; Lelievre, J.; Ballell, L.; Kazaková, E.; Makarov, V.; Marengo, E.; Mikušová, K.; Cole, S. T.; Riccardi, G.; Ekins, S.; Pasca, M. R., A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK. Scientific Reports 2018, 8 (1), 3187. doi:10.1038/s41598-018-21614-4

2017

Huszár, S. ; Singh, V.; Polčicová, A.; Baráth, P.; Barrio, M.B.; Lagrange, S.; Leblanc, V.; Nacy, C.A.; Mizrahi, V.; Mikušová, K., N-Acetylglucosamine-1-Phosphate transferase, WecA, as a validated drug target in Mycobacterium tuberculosis. Antimicrobial Agents Chemotheraphy 2017, 61(11).                    Doi: 10.1128/AAC.01310-17

Degiacomi, G.; Benjak, A.; Madacki, J.; Boldrin, F.; Provvedi, R.; Palu, G.; Kordulakova, J.; Cole, S. T.; Manganelli, R., Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression. Scientific Reports 2017, 7, 43495. Doi: 10.1038/srep43495

Oliveira, P. F. M.; Guidetti, B.; Chamayou, A.; Andre-Barres, C.; Madacki, J.; Kordulakova, J.; Mori, G.; Orena, B. S.; Chiarelli, L. R.; Pasca, M. R.; Lherbet, C.; Carayon, C.; Massou, S.; Baron, M.; Baltas, M., Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity. Molecules 2017, 22 (9). Doi: 10.3390/molecules22091457

 Singh, V.; Dhar, N.; Pato, J.; Kolly, G. S.; Kordulakova, J.; Forbak, M.; Evans, J. C.; Szekely, R.; Rybniker, J.; Palcekova, Z.; Zemanova, J.; Santi, I.; Signorino-Gelo, F.; Rodrigues, L.; Vocat, A.; Covarrubias, A. S.; Rengifo, M. G.; Johnsson, K.; Mowbray, S.; Buechler, J.; Delorme, V.; Brodin, P.; Knott, G. W.; Ainsa, J. A.; Warner, D. F.; Keri, G.; Mikusova, K.; McKinney, J. D.; Cole, S. T.; Mizrahi, V.; Hartkoorn, R. C., Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria. Molecular Microbiology 2017, 103 (1), 13-25. Doi: 10.1111/mmi.13535

Mikusova, K.; Ekins, S., Learning from the past for TB drug discovery in the future. Drug Discovery Today 2017, 22 (3), 534-545. Doi: 10.1016/j.drudis.2016.09.025

Esposito, M.; Szadocka, S.; Degiacomi, G.; Orena, B. S.; Mori, G.; Piano, V.; Boldrin, F.; Zemanova, J.; Huszar, S.; Barros, D.; Ekins, S.; Lelievre, J.; Manganelli, R.; Mattevi, A.; Pasca, M. R.; Riccardi, G.; Ballell, L.; Mikusova, K.; Chiarelli, L. R., A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors. ACS Infectious Diseases 2017.
Doi: 10.1021/acsinfecdis.7b00006

2016

Matviiuk, T.; Madacki, J.; Mori, G.; Orena, B. S.; Menendez, C.; Kysil, A.; Andre-Barres, C.; Rodriguez, F.; Kordulakova, J.; Mallet-Ladeira, S.; Voitenko, Z.; Pasca, M. R.; Lherbet, C.; Baltas, M., Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis. European Journal of Medicinal Chemistry 2016, 123, 462-75. Doi: 10.1016/j.ejmech.2016.07.028

Tiwari, R.; Miller, P. A.; Chiarelli, L. R.; Mori, G.; Sarkan, M.; Centarova, I.; Cho, S.; Mikusova, K.; Franzblau, S. G.; Oliver, A. G.; Miller, M. J., Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043. ACS Medicinal Chemistry Letters 2016, 7 (3), 266-70. Doi: 10.1021/acsmedchemlett.5b00424

 Karabanovich, G.; Zemanova, J.; Smutny, T.; Szekely, R.; Sarkan, M.; Centarova, I.; Vocat, A.; Pavkova, I.; Conka, P.; Nemecek, J.; Stolarikova, J.; Vejsova, M.; Vavrova, K.; Klimesova, V.; Hrabalek, A.; Pavek, P.; Cole, S. T.; Mikusova, K.; Roh, J., Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry 2016, 59 (6), 2362-80.               
Doi: 10.1021/acs.jmedchem.5b00608

 Grzegorzewicz, A. E.; de Sousa-d'Auria, C.; McNeil, M. R.; Huc-Claustre, E.; Jones, V.; Petit, C.; Angala, S. K.; Zemanova, J.; Wang, Q.; Belardinelli, J. M.; Gao, Q.; Ishizaki, Y.; Mikusova, K.; Brennan, P. J.; Ronning, D. R.; Chami, M.; Houssin, C.; Jackson, M., Assembling of the Mycobacterium tuberculosis Cell Wall Core. Journal of Biological Chemistry  2016, 291 (36), 18867-79.                       
Doi: 10.1074/jbc.M116.739227

 Albesa-Jove, D.; Svetlikova, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-Gonzalez, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S. K.; Cifuente, J. O.; Kordulakova, J.; Jackson, M.; Mikusova, K.; Guerin, M. E., Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nature Communications 2016, 7, 10906. Doi: 10.1038/ncomms10906

2015

Chollet, A.; Mori, G.; Menendez, C.; Rodriguez, F.; Fabing, I.; Pasca, M. R.; Madacki, J.; Kordulakova, J.; Constant, P.; Quemard, A.; Bernardes-Genisson, V.; Lherbet, C.; Baltas, M., Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. European Journal of Medicinal Chemistry 2015, 101, 218-35. Doi:10.1016/j.ejmech.2015.06.035

 Grzegorzewicz, A. E.; Eynard, N.; Quemard, A.; North, E. J.; Margolis, A.; Lindenberger, J. J.; Jones, V.; Kordulakova, J.; Brennan, P. J.; Lee, R. E.; Ronning, D. R.; McNeil, M. R.; Jackson, M., Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone. ACS Infectious Diseases 2015, 1 (2), 91-97. Doi: 10.1021/id500032q

 Sipos, A.; Pato, J.; Szekely, R.; Hartkoorn, R. C.; Kekesi, L.; Orfi, L.; Szantai-Kis, C.; Mikusova, K.; Svetlikova, Z.; Kordulakova, J.; Nagaraja, V.; Godbole, A. A.; Bush, N.; Collin, F.; Maxwell, A.; Cole, S. T.; Keri, G., Lead selection and characterization of antitubercular compounds using the Nested Chemical Library. Tuberculosis 2015, 95 Suppl 1, S200-6. Doi: 10.1016/j.tube.2015.02.028

 Singh, V.; Brecik, M.; Mukherjee, R.; Evans, J. C.; Svetlikova, Z.; Blasko, J.; Surade, S.; Blackburn, J.; Warner, D. F.; Mikusova, K.; Mizrahi, V., The complex mechanism of antimycobacterial action of 5-Fluorouracil. Chemistry and Biology 2015, 22 (1), 63-75. Doi: 10.1016/j.chembiol.2014.11.006

 Mori, G.; Chiarelli, L. R.; Esposito, M.; Makarov, V.; Bellinzoni, M.; Hartkoorn, R. C.; Degiacomi, G.; Boldrin, F.; Ekins, S.; de Jesus Lopes Ribeiro, A. L.; Marino, L. B.; Centarova, I.; Svetlikova, Z.; Blasko, J.; Kazakova, E.; Lepioshkin, A.; Barilone, N.; Zanoni, G.; Porta, A.; Fondi, M.; Fani, R.; Baulard, A. R.; Mikusova, K.; Alzari, P. M.; Manganelli, R.; de Carvalho, L. P.; Riccardi, G.; Cole, S. T.; Pasca, M. R., Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chemistry and Biology 2015, 22 (7), 917-27.
Doi: 10.1016/j.chembiol.2015.05.016

 Makarov, V.; Neres, J.; Hartkoorn, R. C.; Ryabova, O. B.; Kazakova, E.; Sarkan, M.; Huszar, S.; Piton, J.; Kolly, G. S.; Vocat, A.; Conroy, T. M.; Mikusova, K.; Cole, S. T., The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 2015, 59 (8), 4446-52. Doi: 10.1128/AAC.00778-15

 Kolly, G. S.; Mukherjee, R.; Kilacskova, E.; Abriata, L. A.; Raccaud, M.; Blasko, J.; Sala, C.; Dal Peraro, M.; Mikusova, K.; Cole, S. T., GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis. Journal of Bacteriology 2015,197 (23),3686-97. Doi: 10.1128/JB.00628-15

 Brecik, M.; Centarova, I.; Mukherjee, R.; Kolly, G. S.; Huszar, S.; Bobovska, A.; Kilacskova, E.; Mokosova, V.; Svetlikova, Z.; Sarkan, M.; Neres, J.; Kordulakova, J.; Cole, S. T.; Mikusova, K., DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. ACS Chemical Biology 2015, 10 (7), 1631-6. Doi: 10.1021/acschembio.5b00237

 Servusova-Vanaskova, B.; Jandourek, O.; Paterova, P.; Kordulakova, J.; Plevakova, M.; Kubicek, V.; Kucera, R.; Garaj, V.; Naesens, L.; Kunes, J.; Dolezal, M.; and Zitko, J., Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation. MedChemComm 2015, 6, 1311-1317. Doi: 10.1039/C5MD00178A

2014

Svetlikova, Z.; Barath, P.; Jackson, M.; Kordulakova, J.; Mikusova, K., Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside. Protein Expression and Purification 2014, 100, 33-9.
Doi: 10.1016/j.pep.2014.04.014

Mikusova, K.; Makarov, V.; Neres, J., DprE1 - from the Discovery to the Promising Tuberculosis Drug Target. Current Pharmaceutical Design 2014, 20 (27), 4379-403.

Boldrin, F.; Ventura, M.; Degiacomi, G.; Ravishankar, S.; Sala, C.; Svetlikova, Z.; Ambady, A.; Dhar, N.; Kordulakova, J.; Zhang, M.; Serafini, A.; Vishwas, V. G.; Kolly, G. S.; Kumar, N.; Palu, G.; Guerin, M. E.; Mikusova, K.; Cole, S. T.; Manganelli, R., The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo. Journal of Bacteriology 2014, 196 (19), 3441-51. Doi: 10.1128/JB.01346-13

Ang, M. L.; Siti, Z. Z.; Shui, G.; Dianiskova, P.; Madacki, J.; Lin, W.; Koh, V. H.; Martinez Gomez, J. M.; Sudarkodi, S.; Bendt, A.; Wenk, M.; Mikusova, K.; Kordulakova, J.; Pethe, K.; Alonso, S., An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition. Infection and Immunity 2014, 82 (5), 1850-9. Doi: 10.1128/IAI.01332-13

2013

Wang, F.; Sambandan, D.; Halder, R.; Wang, J.; Batt, S. M.; Weinrick, B.; Ahmad, I.; Yang, P.; Zhang, Y.; Kim, J.; Hassani, M.; Huszar, S.; Trefzer, C.; Ma, Z.; Kaneko, T.; Mdluli, K. E.; Franzblau, S.; Chatterjee, A. K.; Johnson, K.; Mikusova, K.; Besra, G. S.; Futterer, K.; Jacobs, W. R., Jr.; Schultz, P. G., Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proceedings of the National Academy of Sciences of the United States of America 2013, 110 (27), E2510-7.
Doi: 10.1073/pnas.1309171110

Lattová, E.; Svetlíková, Z.; Mikušová, K.; Perreault, H.; Poláková, M., Novel synthetic (1 → 6)-α-d-mannodisaccharide substrates support processive mannosylation catalysed by the mycobacterial cell envelope enzyme fraction. RSC Advances 2013, 3 (39), 17784. Doi: 10.1039/c3ra43575j

2012

Grzegorzewicz, A. E.; Pham, H.; Gundi, V. A.; Scherman, M. S.; North, E. J.; Hess, T.; Jones, V.; Gruppo, V.; Born, S. E.; Kordulakova, J.; Chavadi, S. S.; Morisseau, C.; Lenaerts, A. J.; Lee, R. E.; McNeil, M. R.; Jackson, M., Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nature Chemical Biology 2012, 8 (4), 334-41. Doi: 10.1038/nchembio.794

Grzegorzewicz, A. E.; Kordulakova, J.; Jones, V.; Born, S. E.; Belardinelli, J. M.; Vaquie, A.; Gundi, V. A.; Madacki, J.; Slama, N.; Laval, F.; Vaubourgeix, J.; Crew, R. M.; Gicquel, B.; Daffe, M.; Morbidoni, H. R.; Brennan, P. J.; Quemard, A.; McNeil, M. R.; Jackson, M., A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. Journal of Biological Chemistry 2012, 287 (46), 38434-41. Doi: 10.1074/jbc.M112.400994

Trefzer, C.; Skovierova, H.; Buroni, S.; Bobovska, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M. R.; Makarov, V.; Cole, S. T.; Riccardi, G.; Mikusova, K.; Johnsson, K., Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1. Journal of the American Chemical Society 2012, 134 (2), 912-5. Doi: 10.1021/ja211042r

Larrouy-Maumus, G.; Skovierova, H.; Dhouib, R.; Angala, S. K.; Zuberogoitia, S.; Pham, H.; Villela, A. D.; Mikusova, K.; Noguera, A.; Gilleron, M.; Valentinova, L.; Kordulakova, J.; Brennan, P. J.; Puzo, G.; Nigou, J.; Jackson, M., A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria. Journal of Biological Chemistry 2012, 287 (47), 39933-41. Doi: 10.1074/jbc.M112.400986

Bodor, R.; Pastierová, A.; Halašiová, M.; Beláňová, M.; Mikušová, K.; Masár, M., Protein Separation and Enzyme Purification by Preparative Capillary Isotachophoresis. Chromatographia 2012, 76 (7-8), 321-327. Doi: 10.1007/s10337-012-2348-8

2011

Brown, J. R.; North, E. J.; Hurdle, J. G.; Morisseau, C.; Scarborough, J. S.; Sun, D.; Kordulakova, J.; Scherman, M. S.; Jones, V.; Grzegorzewicz, A.; Crew, R. M.; Jackson, M.; McNeil, M. R.; Lee, R. E., The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorganic and Medical Chemistry 2011, 19 (18), 5585-95. Doi: 10.1016/j.bmc.2011.07.034

Polakova, M.; Belanova, M.; Mikusova, K.; Lattova, E.; Perreault, H., Synthesis of 1,2,3-triazolo-linked octyl (1-->6)-alpha-D-oligomannosides and their evaluation in mycobacterial mannosyltransferase assay. Bioconjugate Chemistry 2011, 22 (2), 289-98. Doi: 10.1021/bc100421g

Dianiskova, P.; Kordulakova, J.; Skovierova, H.; Kaur, D.; Jackson, M.; Brennan, P. J.; Mikusova, K., Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster. General Physiology and Biophysics 2011, 30 (3), 239-50. Doi: 10.4149/gpb_2011_03_239

2010

Guerin, M. E.; Kordulakova, J.; Alzari, P. M.; Brennan, P. J.; Jackson, M., Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria. Journal of Biological Chemistry 2010, 285 (44), 33577-83. Doi: 10.1074/jbc.R110.168328

Termentzi, A.; Khouri, I.; Gaslonde, T.; Prado, S.; Saint-Joanis, B.; Bardou, F.; Amanatiadou, E. P.; Vizirianakis, I. S.; Kordulakova, J.; Jackson, M.; Brosch, R.; Janin, Y. L.; Daffe, M.; Tillequin, F.; Michel, S., Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring. European Journal of Medicinal Chemistry 2010, 45 (12), 5833-47. Doi: 10.1016/j.ejmech.2010.09.048

Skovierova, H.; Larrouy-Maumus, G.; Pham, H.; Belanova, M.; Barilone, N.; Dasgupta, A.; Mikusova, K.; Gicquel, B.; Gilleron, M.; Brennan, P. J.; Puzo, G.; Nigou, J.; Jackson, M., Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis. Journal of Biological Chemistry 2010, 285 (53), 41348-55. Doi: 10.1074/jbc.M110.188110

Polakova, M.; Belanova, M.; Petrus, L.; Mikusova, K., Synthesis of alkyl and cycloalkyl alpha-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay. Carbohydrate Research 2010, 345 (10), 1339-47.
Doi: 10.1016/j.carres.2010.03.011

Peltier, P.; Belanova, M.; Dianiskova, P.; Zhou, R.; Zheng, R. B.; Pearcey, J. A.; Joe, M.; Brennan, P. J.; Nugier-Chauvin, C.; Ferrieres, V.; Lowary, T. L.; Daniellou, R.; Mikusova, K., Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis. Chemistry and Biology 2010, 17 (12), 1356-66.
Doi: 10.1016/j.chembiol.2010.10.014

Manina, G.; Bellinzoni, M.; Pasca, M. R.; Neres, J.; Milano, A.; Ribeiro, A. L.; Buroni, S.; Skovierova, H.; Dianiskova, P.; Mikusova, K.; Marak, J.; Makarov, V.; Giganti, D.; Haouz, A.; Lucarelli, A. P.; Degiacomi, G.; Piazza, A.; Chiarelli, L. R.; De Rossi, E.; Salina, E.; Cole, S. T.; Alzari, P. M.; Riccardi, G., Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance. Molecular Microbiology 2010, 77 (5), 1172-85. 
Doi: 10.1111/j.1365-2958.2010.07277.x

2009

Makarov, V.; Manina, G.; Mikusova, K.; Mollmann, U.; Ryabova, O.; Saint-Joanis, B.; Dhar, N.; Pasca, M. R.; Buroni, S.; Lucarelli, A. P.; Milano, A.; De Rossi, E.; Belanova, M.; Bobovska, A.; Dianiskova, P.; Kordulakova, J.; Sala, C.; Fullam, E.; Schneider, P.; McKinney, J. D.; Brodin, P.; Christophe, T.; Waddell, S.; Butcher, P.; Albrethsen, J.; Rosenkrands, I.; Brosch, R.; Nandi, V.; Bharath, S.; Gaonkar, S.; Shandil, R. K.; Balasubramanian, V.; Balganesh, T.; Tyagi, S.; Grosset, J.; Riccardi, G.; Cole, S. T., Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 2009, 324 (5928), 801-4.
Doi: 10.1126/science.1171583

Liav, A.; Ciepichal, E.; Swiezewska, E.; Bobovská, A.; Dianišková, P.; Blaško, J.; Mikušová, K.; Brennan, P. J., Stereoselective syntheses of heptaprenylphosphoryl β-d-arabino-and β-d-ribo-furanoses. Tetrahedron Letters 2009, 50 (19), 2242-2244. Doi: 10.1016/j.tetlet.2009.02.188

Skovierova, H.; Larrouy-Maumus, G.; Zhang, J.; Kaur, D.; Barilone, N.; Kordulakova, J.; Gilleron, M.; Guadagnini, S.; Belanova, M.; Prevost, M. C.; Gicquel, B.; Puzo, G.; Chatterjee, D.; Brennan, P. J.; Nigou, J.; Jackson, M., AftD, a novel essential arabinofuranosyltransferase from mycobacteria. Glycobiology 2009, 19 (11), 1235-47. Doi: 10.1093/glycob/cwp116

Guerin, M. E.; Schaeffer, F.; Chaffotte, A.; Gest, P.; Giganti, D.; Kordulakova, J.; van der Woerd, M.; Jackson, M.; Alzari, P. M., Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis. Journal of Biological Chemistry 2009, 284 (32), 21613-25. Doi: 10.1074/jbc.M109.003947

2008

Belanova, M.; Dianiskova, P.; Brennan, P. J.; Completo, G. C.; Rose, N. L.; Lowary, T. L.; Mikusova, K., Galactosyl transferases in mycobacterial cell wall synthesis. Journal of Bacteriology 2008, 190 (3), 1141-5. Doi: 10.1128/JB.01326-07

2007

Kordulakova, J.; Janin, Y. L.; Liav, A.; Barilone, N.; Dos Vultos, T.; Rauzier, J.; Brennan, P. J.; Gicquel, B.; Jackson, M., Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 2007, 51 (11), 3824-9. Doi: 10.1128/AAC.00433-07

Marsollier, L.; Brodin, P.; Jackson, M.; Kordulakova, J.; Tafelmeyer, P.; Carbonnelle, E.; Aubry, J.; Milon, G.; Legras, P.; Andre, J. P.; Leroy, C.; Cottin, J.; Guillou, M. L.; Reysset, G.; Cole, S. T., Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis. PLoS Pathogens 2007, 3 (5), e62. Doi: 10.1371/journal.ppat.0030062

Homerova, D.; Surdova, K.; Mikusova, K.; Kormanec, J., Identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress-response sigma factor sigma(F). Archives of Microbiology 2007, 187 (3), 185-97. Doi: 10.1007/s00203-006-0185-6

Guerin, M. E.; Kordulakova, J.; Schaeffer, F.; Svetlikova, Z.; Buschiazzo, A.; Giganti, D.; Gicquel, B.; Mikusova, K.; Jackson, M.; Alzari, P. M., Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. Journal of Biological Chemistry 2007, 282 (28), 20705-14. Doi: 10.1074/jbc.M702087200

Stadthagen, G.; Sambou, T.; Guerin, M.; Barilone, N.; Boudou, F.; Kordulakova, J.; Charles, P.; Alzari, P. M.; Lemassu, A.; Daffe, M.; Puzo, G.; Gicquel, B.; Riviere, M.; Jackson, M., Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis. Journal of Biological Chemistry 2007, 282 (37), 27270-6. Doi: 10.1074/jbc.M702676200

2006

Mikusova, K.; Belanova, M.; Kordulakova, J.; Honda, K.; McNeil, M. R.; Mahapatra, S.; Crick, D. C.; Brennan, P. J., Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall. Journal of Bacteriology 2006, 188 (18), 6592-8. Doi: 10.1128/JB.00489-06

2005

Mikusova, K.; Huang, H.; Yagi, T.; Holsters, M.; Vereecke, D.; D'Haeze, W.; Scherman, M. S.; Brennan, P. J.; McNeil, M. R.; Crick, D. C., Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose. Journal of Bacteriology 2005, 187 (23), 8020-5.     
Doi: 10.1128/JB.187.23.8020-8025.2005

Stadthagen, G.; Kordulakova, J.; Griffin, R.; Constant, P.; Bottova, I.; Barilone, N.; Gicquel, B.; Daffe, M.; Jackson, M., p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis. Journal of Biological Chemistry 2005, 280 (49), 40699-706. Doi: 10.1074/jbc.M508332200

Guerin, M. E.; Buschiazzo, A.; Kordulakova, J.; Jackson, M.; Alzari, P. M., Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis. Acta crystallographica. Section F, Structural Biology and Crystallization Communications 2005, 61 (Pt 5), 518-20. Doi: 10.1107/S1744309105012364

2003

Yagi, T.; Mahapatra, S.; Mikusova, K.; Crick, D. C.; Brennan, P. J., Polymerization of mycobacterial arabinogalactan and ligation to peptidoglycan. Journal of Biological Chemistry 2003, 278 (29), 26497-504. Doi: 10.1074/jbc.M302216200

Kordulakova, J.; Gilleron, M.; Puzo, G.; Brennan, P. J.; Gicquel, B.; Mikusova, K.; Jackson, M., Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. Journal of Biological Chemistry 2003, 278 (38), 36285-95.
Doi: 10.1074/jbc.M303639200

2002

Kordulakova, J.; Gilleron, M.; Mikusova, K.; Puzo, G.; Brennan, P. J.; Gicquel, B.; Jackson, M., Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. Journal of Biological Chemistry 2002, 277 (35), 31335-44.
Doi: 10.1074/jbc.M204060200

1995 - 2001

Mikusova, K.; Yagi, T.; Stern, R.; McNeil, M. R.; Besra, G. S.; Crick, D. C.; Brennan, P. J., Biosynthesis of the galactan component of the mycobacterial cell wall. Journal of Biological Chemistry 2000, 275 (43), 33890-7. Doi: 10.1074/jbc.M006875200

Mikusova, K.; Mikus, M.; Besra, G. S.; Hancock, I.; Brennan, P. J., Biosynthesis of the linkage region of the mycobacterial cell wall. Journal of Biological Chemistry 1996, 271 (13), 7820-8.

Khoo, K. H.; Douglas, E.; Azadi, P.; Inamine, J. M.; Besra, G. S.; Mikusova, K.; Brennan, P. J.; Chatterjee, D., Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol. Journal of Biological Chemistry 1996, 271 (45), 28682-90.

Belanger, A. E.; Besra, G. S.; Ford, M. E.; Mikusova, K.; Belisle, J. T.; Brennan, P. J.; Inamine, J. M., The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proceedings of the National Academy of Sciences of the United States of America 1996, 93 (21), 11919-24.

Mikusova, K.; Slayden, R. A.; Besra, G. S.; Brennan, P. J., Biogenesis of the mycobacterial cell wall and the site of action of ethambutol. Antimicrobial Agents and Chemotherapy 1995, 39 (11), 2484-9.

Lee, R. E.; Mikušová, K.; Brennan, P. J.; Besra, G. S., Synthesis of the mycobacterial arabinose donor, beta-D-arabinofuranosyl-1-monophosphoryldecaprenol, development of basic arabinosyl-transferase assay, and identification of ethambutol as an arabinosyltransferase inhibitor. Journal of the American Chemical Society 1995, 117, 11829-11832.  Doi: 10.1021/ja00153a002

Deng, L.; Mikusova, K.; Robuck, K. G.; Scherman, M.; Brennan, P. J.; McNeil, M. R., Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope. Antimicrobial Agents and Chemotherapy 1995, 39 (3), 694-701.