Since its establishment in 1919 Comenius University (CU) maintains and widens its international relations with significant European educational institutions. After the so called Velvet Revolution and the fall of the totalitarian regime in 1989 the portfolio of bilateral agreements between CU and its thirteen faculties was significantly widened. The fact that CU as the oldest and biggest university educational institution in Slovakia fulfills the role of “national university” and belongs to the most important European university associations plays an important role in this field. It is the member of European University Association (EUA), Network of Universities of the Capitals of Europe (UNICA), Utrecht Network, Danube Rector’s Conference (DRC), European Association of International Education (EAIE), Virtual Technology Library Systems (VTLS) and many other. The fact that since May 1, 2004 Slovak Republic has been the member of the European Union and since 2000 also the member of OECD is of high importance too. In connection to CU participation in the Lifelong Learning Program/Erasmus program (LLP/, Erasmus since January 1, 2007, Erasmus+ since June 1, 2014) the number of bilateral agreements entered among faculties of CU and their foreign partners grew considerably.