The Laboratory of Cognitive and Adaptative Neurosciences (LNCA, UMR7364) is a research intensive department of the University of Strasbourg characterized by a dynamic community of scientists driven by the desire to understand biological bases of cognition with diverse perspectives from genes to behavior (web site). The LNCA group “ENGRAM” is seeking a post-doctoral fellow with a PhD in Neurosciences or related fields. The position is fully funded for 12 to 18 months by a University of Strasbourg IdEx (initiative of excellence) support which requires the PhD to be obtained in a different university and after the 1 st of January, 2014.
The aim of the research project is to explore the therapeutic potential of a newly identified target related to melatonin in the APP KI x Tau KI mice, a second generation model of Alzheimer’s disease. Behavioral (WT et target-KO mice), pharmacological (original compounds), immunohistological (apotome microscopy – NeuroLucida) and electrophysiological (oscillatory activity) approaches will be combined to evaluate the efficacy of the treatment and further characterize the mechanisms of action.
The successful applicant will have strong background in Neurosciences, an experience in working with rodents (preferably mice) and at least one of the following domains: melatoninergic system, learning and memory processes and/or mouse models of Alzheimer’s disease. As the Fellow will be directly involved in the designing of protocols, data collection, data analysis, and writing of scientific article, previous experience in each of these aspects of research is clear advantage.
The position follows standard French academic research salaries and is available the 1st of June 2018, although the specific start date is negotiable. To apply for this position, please send a curriculum vita with three references and a list of publications, as well as a cover letter describing research interest and experience to Chantal Mathis (email@example.com; e-mail).
Project Outline: A PhD position is currently available in the laboratory of Maria Robles, Systems Chronobiology, at the LMU Munich, Germany. The Robles group employs mass spectrometry based quantitative proteomics to study the circadian clock, the biological pacemaker that regulates physiology and behavior. We utilize state of the art quantitative proteomic methods to characterize daily rhythms of protein abundance, post-translational modification and protein-protein interactions in different cellular and in vivo models. We complement our proteomics methods with a broad range of genomic, molecular and cell biology techniques.
We seek: We are looking for independent and motivated doctorate students interested in a multidisciplinary approach to study circadian function as well as metabolic, and behavioral disorders associated with circadian asynchrony. Applicants should have experience with mammalian cell culture, routine molecular and cell biology. Proteomics and bioinformatics expertise is an advantage, but certainly not required.
We offer: Funded 3-year position with a salary of 65% of TV-L 13.
- Cutting edge research project at the interface proteomics and chronobiology
- International networking and exchange opportunities
- The opportunity to become a student in the International PhD program IMPRS for Molecular Life Sciences
- Close mentorship
- Excellent scientific environment in one of the top-ranked universities in Germany.
To apply Please send, before June 30, 2018,
- a detailed CV,
- a cover letter with motivation and
- goals and contact information of 2-3 referees to
Contact: Prof. Maria Robles. PhD.
Position: Funded 3-year position for a post-doctoral fellow. The position is vacant from April, 2018.
Project Outline: Our environment is characterized by constant changes between day and night. Most organisms, including humans, have evolved so called circadian clocks (internal ~24 h clocks) in order to adapt virtually all physiological processes to these daily changes. A disturbance of circadian rhythms has far-reaching consequences on our health. The focus of our studies is the characterization of causal connections between disturbed circadian clocks and psychiatric and metabolic disorders. The successful applicant’s project will include intensive work with animal models (mice) and human patients. Since the aim is an investigation reaching from molecules to behaviors, the studies will employ a broad spectrum of molecular, genetic, cell/tissue culture, cell imaging, surgical (rodent), and behavioral (rodent) techniques.
Candidate Requirements: Applicants should have a PhD in a related field, a demonstrated track record of productivity, and experience in most techniques mentioned above. Experiences in human studies and microdialysis are a plus, but are not required. Our laboratory is seeking for efficient, active, and creative candidates. Qualified candidates will be expected to work both independently and as part of an interactive team. The applicants should feel comfortable with the English language.
What we offer: The Ludwig Maximilian University is ranked 66th in the world and one of the top-ranked universities in Germany. Our laboratory is a motivating and supportive environment embedded in the University Clinic for Psychiatry and Psychotherapy. This special location allows a great overlap between basic and clinical research as the close collaboration between researchers and medical doctors is a major goal of the hospital. The attractive field of circadian science opens broad application possibilities and has not only enjoyed great prestige since the award of the Nobel Prize in Physiology or Medicine in 2017.
The following documents should be send by June 15, 2018 at the latest (preferably in pdf format):
- detailed CV,
- a cover letter with a statement of research interests and career goals, 3. name, email address and phone numbers of three references.
Contact: Dr. Dominic Landgraf
- looking for a PhD position now/starting in September 2018?
- curious about human embryonic stem cells?
- familiar with molecular or cell biology?
Our group uses human embryonic stem cells to model neural differentiation in vitro. Using several model systems, we study:
- Molecular mechanisms of neural differentiation (How is the differentiation regulated on a molecular level? Is cell division cycle involved? Do microRNA contribute to this process?)
- Cerebral organoids, Alzheimer’s disease and p53 (Can we create “minibrains” in the dish? Can we model Alzheimer’s disease in vitro? Is p53protein necessary for neuronal development?)
We are looking for PhD candidate(s):
- fascinated by how cells differentiate and how this process is regulated
- familiar with basic methods of molecular biology and/or cell culture
- able to work independently on their own project and also willing to help others when needed
- eager to apply for theirown (student’s) grants and attend scientific conferences
- friendly, outgoing, and smart
You will gain experience in:
- human embryonic stem cell culture and differentiation protocols
- basic and advanced molecular biology techniques
- data evaluation and presentation
- grant proposal and manuscript writing
- …and more!
All nationalities welcome!
How to apply:
Send a letter of interest and CV to:
Dáša Bohačiaková, PhD
Department of Histology and Embryology Faculty of Medicine
Masaryk University Brno, Czech republic