Prírodovedecká fakultaUniverzity Komenského v Bratislave

2018/05/10 Prednáška Metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention

Katedra živočíšnej fyziológie a etológie

a Katedra organickej chémie

Prírodovedecká fakulta UK

si Vás dovoľujú pozvať na prednášku

Prof. Miguel Ángel Medina (University of Málaga, Spain)

Metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention

Prednáška sa uskutoční v konferenčnom centre AMOS

štvrtok 10. mája 2018 o 16:30 hod.

Prof. MEDINA TORRES MIGUEL ÁNGEL

Universidad de Málaga Full Professor (Catedrático) 2009-present

Education

Graduate in Biology 1985 Facultad Ciencias. Univ. de Málaga, Spain.
Ph. D. in Biology 1989 Facultad Ciencias. Univ. de Málaga, Spain.
Predoc 1988 McGill University. Montreal, Canadá.
Postdoc 1989 MaxPlanck Institut, Dortmund, Germany.
Postdoc 1992 Heidelberg University, Heidelberg, Germany.
Invited researcher 2001 Max Planck Institut, Göttingen, Germany.
Graduate in History of Art 2010 University of Málaga, Spain.

Research interests

(i) main field: Modulation of angiogenesis. Systems Biology. Metabolic modeling. Rare diseases.

(ii) other fields: Plasma membrane redox systems in tumor and endothelial cells. Membrane transport systems. Relevance of nitrogen compounds (amino acids, polyamines) in endothelial and cancer cell proliferation and invasion. Tumor metabolism.

(iii) current research interest: Search for compounds with modulatory effects on angiogenesis. Caracterization of the structure/function relationship and turnover mechanisms of L-amino acid decarboxylases in Eukaryotes: Molecular basis and pharmacological implications. Anti-inflammatory strategies. Application of bioinformatics, biophysical and systems biology approaches to the study of polyamine and biogenic amine metabolism and to the systemic study of rare diseases.

Selected publicationftom 2 last years

Reyes-Palomares A, Bueno A, Rodríguez-López R, Medina MA, Sánchez-Jiménez F, Ranea JAG. Systematic identification of phenotypically enriched loci using a patient network of genomic disorders. BMC Genomics 17: (2016)
García-Vilas JA, Martínez-Poveda B, Quesada AR, Medina MA. Aeroplysinin-1, a sponge-derived multi-targeted bioactive marine drug. Marine Drugs 14: 1 (2016)
García-Caballero M, Blacher S, Paupert J, Quesada AR, Medina MA, Noël A. Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway Br J Pharmacol 173: 1966-1987 (2016)
García-Caballero M, Martínez-Poveda B, Medina MA, Quesada AR. Targeting tumor angiogenesis for cancer prevention. In: Molecular Targets and Strategies in Cancer Prevention (Chatterjee M, ed), pp. 117-149. Springer, Basel (2016)
García-Vilas JA, Quesada AR, Medina MA. Screening of synergistic interactions of epigallocatechin-3-gallate with antiangiogenic and antitumor compounds. Synergy 3: 5-13 (2016)
García-Vilas JA, Quesada AR, Medina MA. Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibtis both ex vivo and in vivo angiogenesis. Food Chem 221: 1741-1746 (2017)
García-Vilas JA, Pino-Ángeles, A, Martínez-Poveda B, Quesada AR, Medina MA. The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects. Cancer Lett 385: 1-11 (2017)
García-Caballero M, Paupert J, Blacher S, Van der Velde M, Quesada AR, Medina MA, Nöel A. Targeting VEGFR-3/-2 signaling patways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases. J Hematol Oncol 10: 122 (2017)
Martínez-Poveda B, Quesada AR, Medina MA. Pleiotropic role of puupehenones in biomedical research. Mar Drugs 15: 325 (2017)
García-Caballero M, Martínez-Poveda B, Medina MA, Quesada AR. The natural antiangiogenic compound AD0157 induces caspase-dependent apoptosis in human myeloid leukemia cells. Front Pharmacol 8: 802 (2017)
Ocaña MC, Martínez-Poveda B, Quesada AR, Medina MA. Metabolism in the tumor microenvironment: what is known about stromal and immune cells? Clin Immunol Endocrine Metab Drugs 4: 33-36 (2017)
García-Caballero M, Quesada AR, Medina MA, Marí-Beffa M. Fishing anti(lympha)angiogenic drugs with zebrafish. Drug Discov Today 23: 366-374 (2018)
Romero-Sánchez LB, Marí-Beffa M, Carrillo P, Medina MA, Díaz-Cuenca A.Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model. Acta Biomaterialia 68: 272-285 (2018)
Medina MA. Mathematical modeling of cancer metabolism. Crit Rev Oncol Hematol 124: 37-40 (2018)

Za organizátorov

Prof. RNDr. Michal Zeman, DrSc.
Department of Animal Physiology and Ethology
Faculty of Natural Sciences,
Comenius University
Ilkovicova 6, B2/421
842 15 Bratislava
Slovak Republic
email: michal.zemanuniba.sk
phone: +421 2 60296424