- The University of Manchester, Faculty of Biology, Medicine and Health Wellcome Trust Centre for Cell-Matrix Research
- 2 years, in the first instance, with the possibility for a third year of funding
- Closing date, 01/07/2017
In this project, we aim to use molecular cell biology, mouse genetics (CRISPR), organoid culture and RNAseq to define how the molecular circadian clock controls goblet cell function and mucin biology, including the homeostasis of mucobiome and the defence against infections. This project builds on expertise and close collaborations between the labs of Qing-Jun Meng (chronobiology), David Thornton (mucin biology), Richard Grencis (infection and immunity).
This post is one of four pilot projects under the new research initiative in fibrosis of The Wellcome Trust Centre for Cell-Matrix Research (WTCCMR), supported by generous funds from the Wellcome Trust, and building on the collaborative culture and excellence in training and technology development in the Centre. The WTCCMR brings together the world’s largest team of Primary Investigators studying cell-matrix interactions. Research is divided into three complementary themes, inspired by groundbreaking discoveries in the field: ‘ImmunoMatrix’ (synergy between matrix and the immune system); ‘MechanoMatrix’ (the biomechanical role of matrix); and ‘ChronoMatrix’ (circadian rhythm and matrix regulation).
Enquiries: Prof. Qing-Jun Meng (qing-jun.meng( at )manchester.ac.uk)
More information: PDF
The selected candidate(s) will join our ongoing efforts to study the links between circadian disruption and psychiatric disorders, and the post-translational modifications of clock proteins.
Expected background of candidates
Candidates should hold a B.Sc. or M.Sc. (to apply for a graduate student position) or a Ph.D. (to apply for a postdoctoral position) in basic biological sciences (e.g. Neuroscience, Biochemistry...) at the time of taking up the position.
How to apply
To apply for a position, the following documents should be sent by email to Dr. Nicolas Cermakian (firstname.lastname@example.org):
- Letter of presentation/motivation
- CV (including list of several reference persons)
- University transcripts (for applicants for graduate student positions)
Place of work: Fribourg
Contract: 1 year, with 2; possible 2-year extensions. Maximum duration is 5 years
Please consult also our web-page at: http://www.unifr.ch/biology
Applicant profile: We are seeking outstanding and highly motivated candidates with a master degree in Biology (major Molecular biology, biochemistry or equivalent), Biomedicine or a closely related field. The position involves a modest amount of assistance in practical courses of the Bachelor/Master curricula in Biology, Biomedicine and Medicine. Good command of English and German or French is expected.